Diboron → HCID 20452655, compound

Participants

Reaction Steps

Selective reduction of the amide group in 3-(4-benzyloxy-3-methoxycarbonyl-phenyl)-propionic acid N-benzylamide using diborane in tetrahydrofuran for a reaction time of 48 hours at a temperature of 20°-25° yields N-[3-(4-benzyloxy-3-methoxycarbonyl-phenyl)-propyl]benzylamine, which, in the form of the crude product, is converted by means of hydrogen in the presence of palladium-on-charcoal catalyst (50%), in methanol as the solvent, at a temperature of 15°-20° to N-[3-(4-hydroxy-3-methoxycarbonylphenyl)-propyl]-benzylamine with a melting point of 75°-77° (from isopropanol).

Provenance & Evidence