5-(2-Aminoethoxy)-2-hydroxybenzamide → 5-[2-(Benzylamino)-ethoxy]-salicylamide

Participants

Reaction Steps

The 5-(2-aminoethoxy)-salicylamide required as starting material is obtained by catalytic debenzylation of 5-(2-benzylamino-ethoxy)-salicylamide by means of a 5% palladium-charcoal catalyst in methanol under normal conditions. After the hydrogen absorption is completed, the catalyst is filtered off, and the filtrate is concentrated under reduced pressure to thus obtain 5-(2-aminoethoxy)-salicylamide, m.p. 140°.

Provenance & Evidence