反应详情

2.7 g of 5-(2-anilinoethoxy)-4-(2,4-dichlorobenzoyl)-1,3-dimethylpyrazole prepared by the procedure of Example 1 or 3 was dissolved in 25 ml of benzene, then 0.7 ml of dimethyl sulphate was added and the mixture heated under reflux for 3 hours with stirring. After cooling of the mixture and washing with water, the organic layer was dried over anhydrous sodium sulphate and the solvent distilled off to give 2.4 g of the desired product, Compound 2, similar to that of Examples 2 and 3 (yield 86%).

1. temperaturethe mixture heated
2. temperatureunder reflux for 3 hours
3. temperatureAfter cooling of the mixture
4. washwashing with water
5. dry with materialthe organic layer was dried over anhydrous sodium sulphate
6. distillationthe solvent distilled off