HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Methyl 2-[2-(4-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Methyl 3-(4-chlorobenzoylamino)-3-(3-thienylcarbonyl)propionate | HCID 13345231 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 2-[2-(4-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate | HCID 13105438 | 89.2% |
Reaction Steps
13 g of methyl 3-(4-chlorobenzoylamino)-3-(3-thienylcarbonyl)propionate, 50 ml of dimethylformamide and 9.6 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 11 g of methyl 2-[2-(4-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate are thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04460596 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-ebfb594b38ac4116a5b32d17b32a23c6 |
| Source note | uspto-grants-1984_07 |