HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Ethyl 2-[2-(4-chlorophenyl)-5-(2-thienyl)-4-oxazolyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 3-(4-chlorobenzoylamino)-3-(2-thienylcarbonyl)propionate | HCID 13105426 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-[2-(4-chlorophenyl)-5-(2-thienyl)-4-oxazolyl]acetate | HCID 13105457 | 83% |
Reaction Steps
2.8 g of ethyl 3-(4-chlorobenzoylamino)-3-(2-thienylcarbonyl)propionate, 10 ml of dimethylformamide and 1.4 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 2.2 g of ethyl 2-[2-(4-chlorophenyl)-5-(2-thienyl)-4-oxazolyl]acetate are thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04460596 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-4988a817a8a24131bea4d90c2cc8d9d6 |
| Source note | uspto-grants-1984_07 |