Methanol → HCID 13105458, compound

HRID 1462403Notes

Reaction equation

HRID 1462403 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.CO.[OH-].[K+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 13105456HCID 13105456, compound

Product 1

HCID 13105458HCID 13105458, compoundYield 91.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

14.0 g of ethyl 2-[2-(4-fluorophenyl)-5-(2-thienyl)-4-oxazolyl]acetate, 300 ml of methanol, 30 ml of water and 5.6 g of potassium hydroxide are treated in the same manner as described in Example 8. 11.7 g of 2-[2-(4-fluorophenyl)-5-(2-thienyl)-4-oxazolyl]acetic acid are thereby obtained.

Sources & evidence

ORD record
ord-fc07cb7e80d743e5aea5e36ed2d562be
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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