Methanol → 2-[2-Phenyl-5-(3-thienyl)-4-oxazolyl]acetic acid

HRID 1462404Notes

Reaction equation

HRID 1462404 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:18]3[CH:22]=[CH:21][S:20][CH:19]=3)=[C:10]([CH2:12][C:13]([O:15]CC)=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[OH-].[K+]>O>[C:1]1([C:7]2[O:8][C:9]([C:18]3[CH:22]=[CH:21][S:20][CH:19]=3)=[C:10]([CH2:12][C:13]([OH:15])=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 13105436Ethyl 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetate

Product 1

HCID 131054392-[2-Phenyl-5-(3-thienyl)-4-oxazolyl]acetic acidYield 88%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

15.0 g of ethyl 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetate, 250 ml of methanol, 20 ml of water and 6.3 g of potassium hydroxide are treated in Example 8. 12.0 g of 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetic acid are thereby obtained. Yield: 88%

Sources & evidence

ORD record
ord-2167cc9dcc9943339c9bb8b431d83f2c
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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