Methanol → HCID 13105454, compound

HRID 1462414Notes

Reaction equation

HRID 1462414 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]([C:19]2[CH:23]=[CH:22][S:21][CH:20]=2)=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=1.CO.[OH-].[K+]>O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]([C:19]2[CH:23]=[CH:22][S:21][CH:20]=2)=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 13105452HCID 13105452, compound

Product 1

HCID 13105454HCID 13105454, compoundYield 89.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.5 g of ethyl 2-[2-(2-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate, 75 ml of methanol, 7.5 g of water and 1.4 g of potassium hydroxide are treated in the same manner as described in Example 8. 2.84 g of 2-[2-(2-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetic acid are thereby obtained.

Sources & evidence

ORD record
ord-9ffdcd6a2aa14bbba214130a3e2bf5ad
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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