HCID 178430866, compound → HCID 178430865, compound

HRID 1462451Notes

Reaction equation

HRID 1462451 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N+:14]([O-])=O)[NH:5][CH:6]=1>[Pd].C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH2:14])[NH:5][CH:6]=1

Participants

4

Reactant 1

HCID 178430866HCID 178430866, compound

Product 1

HCID 178430865HCID 178430865, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 23.44 g of 4-methyl-2-(2-nitrobenzyl)imidazole, 2.34 g of 10% palladium on charcoal and 234 ml of ethanol is hydrogenated at 42 psi (3 atmospheres) at room temperature for 4 hours. The catalyst is filtered and the filtrates are evaporated to dryness to give 4-methyl-2-(2-aminobenzyl)imidazole showing signals in the NMR spectrum at δ2.09, 3.78, 6.08.

Workup

  1. filtrationThe catalyst is filtered
  2. customthe filtrates are evaporated to dryness

Sources & evidence

ORD record
ord-bbb85dd1f84642a4be79e35b592611b1
Source dataset
uspto-grants-1984_07
Patent number
US04460587

Reaction notes

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