Ethoxy(4-phenylbutyl)phosphinyl chloride → HCID 86739557, compound

HRID 1462499Notes

Reaction equation

HRID 1462499 reaction equation
Cl[P:2]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:6])[O:3][CH2:4][CH3:5].[NH2:17][CH:18]1[CH2:23][S:22][C@H:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:20]([CH2:30][C:31]([O:33][CH2:34][CH2:35][Si:36]([CH3:39])([CH3:38])[CH3:37])=[O:32])[C:19]1=[O:40]>>[CH2:4]([O:3][P:2]([NH:17][CH:18]1[CH2:23][S:22][C@H:21]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:20]([CH2:30][C:31]([O:33][CH2:34][CH2:35][Si:36]([CH3:38])([CH3:37])[CH3:39])=[O:32])[C:19]1=[O:40])([CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:6])[CH3:5]

Participants

3

Reactant 2

HCID 15591238Ethoxy(4-phenylbutyl)phosphinyl chlorideHCID 56624470HCID 56624470, compound

Product 1

HCID 86739557HCID 86739557, compound

Procedure

Chloro(4-phenylbutyl)phosphinic acid, ethyl ester is reacted with (R)-dihydro-5-amino-4-oxo-2-phenyl-2H-1,3-thiazine-3(4H)-acetic acid, trimethylsilylethyl ester according to the procedure of Example 1(f) to yield (R)-dihydro-5-[[ethoxy(4-phenylbutyl)phosphinyl]amino]-4-oxo-2-phenyl-2H-1,3-thiazine-3(4H)-acetic acid, trimethylsilylethyl ester.

Sources & evidence

ORD record
ord-7e007d17bb54464b89b22c868a1954c2
Source dataset
uspto-grants-1984_07
Patent number
US04460579

Reaction notes

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