反应详情

温度

50 °C

3.0 6-(1-oxo-2-bromoethyl)-3,4-dihydrocarbostyril and 5.5 g of 4-(3-chlorophenyl)piperazine were dispersed in 50 ml of dioxane and the dispersion was stirred at 50° C. for 5 hours. Then the reaction mixture was cooled and the insoluble matters formed in the reaction mixture were removed and the dioxane mother liquor was concentrated under a reduced pressure to dryness. 80 Milliliter of ether was added to the dried matter to effect the crystallization. Crude crystals thus obtained were recrystallized from dioxane-water to obtain 3.1 g of 6-{1-oxo-2-[4-(3-chlorophenyl)-1-piperazinyl]ethyl}-3,4-dihydrocarbostyril in light yellow needle-like crystals.

1. temperatureThen the reaction mixture was cooled
2. customthe insoluble matters formed in the reaction mixture
3. customwere removed
4. concentrationthe dioxane mother liquor was concentrated under a reduced pressure to dryness
5. addition80 Milliliter of ether was added to the dried matter
6. customthe crystallization
7. customCrude crystals thus obtained
8. customwere recrystallized from dioxane-water