HCID 13064824, compound → HCID 13064850, compound

HRID 1462547Notes

Reaction equation

HRID 1462547 reaction equation
[O:1]=[C:2]([C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[NH:27][C:26](=[O:31])[CH2:25][CH2:24]2)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1.[H][H]>C(O)C.[C].[Pd]>[OH:1][CH:2]([C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[NH:27][C:26](=[O:31])[CH2:25][CH2:24]2)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=2)[CH2:8][CH2:7]1

Participants

5

Reactant 2

HCID 13064824HCID 13064824, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13064850HCID 13064850, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

1.5 Gram of 6-{1-oxo-4-[4-(4-nitrophenyl)-piperazinyl]-butyl}-3,4-dihydrocarbostyril and 0.3 g of 5%-palladium-carbon were dispersed in 150 ml of ethanol and catalytically reduced under 2 kg/cm2 of hydrogen gas for 5 hours. The reaction mixture was filtered and the mother liquor was concentrated under a reduced pressure. The residue thus obtained was recrystallized from methanol to obtain 0.7 g of 6-{1-hydroxy-4-[4-(4-aminophenyl)-1-piperazinyl]butyl}- 3,4-dihydrocarbostyril in brown powdery crystals.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe mother liquor was concentrated under a reduced pressure
  3. customThe residue thus obtained
  4. customwas recrystallized from methanol

Sources & evidence

ORD record
ord-2807111d22e744379314a67e6bce1554
Source dataset
uspto-grants-1984_07
Patent number
US04460593

Reaction notes

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