Diethyl Ether → HCID 53739889, compound

Participants

Reaction Steps

2.8 Grams of 6-{1-hydroxy-4-[4-(2,3- dimethylphenyl)-1-piperazinyl]butyl}-3,4-dihydrocarbostyril and 0.5 g p-toluenesulfonic acid were disposed in 100 ml of dichloroethane then the mixture was refluxed for 20 minutes. The reaction mixture was concentrated under a reduced pressure to dryness then to the residue thus obtained were added 10N-NaOH and diethyl ether and stirred at a room temperature for 30 minutes. The crystals thus precipitated were collected by filtration and separated by a silica-gel chromatography. Recrystallized from ethanol-acetone- chloroform to obtain 6-{4-[4-(2,3-dimethylphenyl)- piperazinyl]-1-butenyl}-3,4-dihydrocarbostyril in coloress needle-like crystals. Yield: 1.9 g.

Provenance & Evidence