HCID 13084736, compound → HCID 13084715, compound

HRID 1462558Notes

Reaction equation

HRID 1462558 reaction equation
O1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[CH2:15][CH2:14]3)[CH2:3][CH2:2]1>NC1C=CC=CC=1>[C:18]1([N:17]2[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]3[CH:12]=[C:13]4[C:18](=[CH:19][CH:20]=3)[NH:17][C:16](=[O:21])[CH2:15][CH2:14]4)[CH2:3][CH2:2]2)[CH:19]=[CH:20][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 1

HCID 13084736HCID 13084736, compound

Product 1

HCID 13084715HCID 13084715, compound

Reagents, catalysts & solvents 1

HCID 6115AnilineSolvent

Procedure

2.88 Grams of 6-(4-morpholinobutyl)-3,4-dihydro-carbostyril and 10 ml of aniline were enclosed in a sealed tube and heated at 170°-200° C. for 5 hours. The reaction mixture was concentrated under a reduced pressure by removing aniline and the residue thus obtained was separated and purified by a silica-gel chromatography. Recrystallized from iropropanoldiisopropyl ether to obtain 0.36 g of 6-[4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril in colorless prism-like crystals having the melting point of 151°-152° C.

Workup

  1. temperatureheated at 170°-200° C. for 5 hours
  2. concentrationThe reaction mixture was concentrated under a reduced pressure
  3. customby removing aniline
  4. customthe residue thus obtained
  5. customwas separated
  6. custompurified by a silica-gel chromatography
  7. customRecrystallized from iropropanoldiisopropyl ether

Sources & evidence

ORD record
ord-0fd8c883991d4cff80413a1bf74a9828
Source dataset
uspto-grants-1984_07
Patent number
US04460593

Reaction notes

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