Hydrogen Bromide → Diacetone L-sorbose

Participants

Reaction Conditions

Reaction Steps

To 200 ml of acetone were added 10.0 g of L-sorbose, 143 mg of cuprous oxide and 173 mg of 47% hydrobromic acid, and the mixture was refluxed in a warm-water bath at 60° C. for 8 hours. The refluxing solvent was continuously dried with 20 g of molecular sieves 3A which was placed between the reaction vessel and the cooling tube. After the conclusion of the reaction, the same post-treatment as in Example 5 was carried out, thus giving 11.0 g (76.2%) of 2,3:4,6-di-O-isopropylidene-L-sorbofuranose.

Provenance & Evidence