Ammonia → HCID 13120747, compound

HRID 1462638Notes

Reaction equation

HRID 1462638 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH:15]=[C:14]2[C:8]([CH2:9][N:10]=[C:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:12]3[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:13]=32)=[N:7]1)C.[NH3:28]>>[Cl:20][C:18]1[CH:17]=[CH:16][C:13]2[C:14]3[C:8](=[N:7][N:6]([CH2:5][C:4]([NH2:28])=[O:3])[CH:15]=3)[CH2:9][N:10]=[C:11]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:12]=2[CH:19]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 53664244HCID 53664244, compound

Product 1

HCID 13120747HCID 13120747, compound

Procedure

Heating a mixture of 0.8 g (2.1 mmol) of 8-chloro-6-phenyl-2H,4H-pyrazolo[3,4-d][2]benzazepine-2-acetic acid ethyl ester and 20 ml of methanolic ammonia (ca. 20%, v/v) in an autoclave on the steam bath for 20 hr gave after crystallization from ethyl acetate/ether colorless crystals with mp 236°-238°. The analytical sample was recrystallized from ethyl acetate/methylene chloride/ether.

Workup

  1. temperatureHeating
  2. customgave
  3. customafter crystallization from ethyl acetate/ether colorless crystals with mp 236°-238°
  4. customThe analytical sample was recrystallized from ethyl acetate/methylene chloride/ether

Sources & evidence

ORD record
ord-7c96822ca18c47a3981ad458bf8a7ba0
Source dataset
uspto-grants-1984_07
Patent number
US04460781

Reaction notes

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