Acrylonitrile → 3-[4-Chloro-2-(2-fluorobenzoyl)phenyl]prop-2-enenitrile

Participants

Reaction Steps

A solution of 5.0 g (14 mmol) of 5-chloro-2'-fluoro-2-iodobenzophenone, 2 mL (14.3 mmol) of triethylamine, 2 mL (30 mmol) of acrylonitrile and 35 mg (1.5 mmol) of palladium acetate was refluxed under an atomsphere of argon for 16 hr. The mixture was diluted with 100 ml of 1N hydrochloric acid and the resulting precipitate was collected by filtration. The precipitate was washed with ether and air dried to give an off-white solid, mp 130°-133°.

Provenance & Evidence