Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-pentyloxyiminoacetic acid

HRID 1462720Notes

Reaction equation

HRID 1462720 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:8]([OH:10])=[O:9])[N:6]=1.[C:18](OC(=O)C)(=[O:20])C>C(O)=O>[CH:18]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:8]([OH:10])=[O:9])[N:6]=1)=[O:20]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 545401762-(2-Aminothiazol-4-yl)-2-pentyloxyiminoacetic acid

Product 1

HCID 538074782-(2-Formamidothiazol-4-yl)-2-pentyloxyiminoacetic acidYield 88.4%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2-(2-Aminothiazol-4-yl)-2-pentyloxyiminoacetic acid (syn isomer, 15 g.), acetic anhydride (23.8 g.) and formic acid (10.7 g.) were treated in a similar manner to that of Example F-(5) to give 2-(2-formamidothiazol-4-yl)-2-pentyloxyiminoacetic acid (syn isomer, 14.7 g.), mp 125° C. (dec.).

Sources & evidence

ORD record
ord-b27270d4a3fb4aa396c56d6c06fc21b6
Source dataset
uspto-grants-1984_07
Patent number
US04460583

Reaction notes

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