Dicyclohexylcarbodiimide → HCID 131713589, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.67 g of Boc-Ser(Bzl), 3.75 g of His(Tos)-Lys(Z)-OBzl and 13.2 ml of methylene chloride was cooled to -15° C., and 1.28 g of DCC was added to the mixture under stirring. Two hours later, the mixture was further stirred at room temperature for 2 hours. Insoluble matters were filtered off and washed with ethyl acetate. The filtrate and the washing were combined and washed with aqueous citric acid, saturated saline and sodium bicarbonate aqueous solution, dried over sodium sulfate anhydride. Then, the solvent was distilled off. The resultant oil residue was crystallized by adding ether to obtain 4.2 g of Boc-Ser(Bzl)-His(Tos)-Lys(Z)-OBzl.

Provenance & Evidence