5-(Cyclopropylmethoxy)pyrazine-2-carboxylic acid → N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)-4-fluorophenyl]-5-(cyclopropylmethoxy)pyrazine-2-carboxamide
Reaction equation
[CH:19]1([CH2:22][O:23][c:24]2[n:25][cH:26][c:27]([C:30](=[O:31])[OH:32])[n:28][cH:29]2)[CH2:20][CH2:21]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1)[C:30]([c:27]1[cH:26][n:25][c:24]([O:23][CH2:22][CH:19]2[CH2:20][CH2:21]2)[cH:29][n:28]1)=[O:31]Participants
3
Sources & evidence
- ORD record
- ord-e43a1efacc3e45babaccf3aea70c9e5a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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