Hydrochloric Acid → HCID 13336746, compound

Participants

Reaction Steps

The (R)(+)-1-(3-benzoylthio-1-oxopropyl)-1,2,3,4-tetrahydro-2-quinolinecarboxylic acid dicyclohexylamine salt thus obtained (4.1 g) was suspended in 2-propanol (25 ml) and this mixture was cooled to 5° and treated with a solution of dry hydrogen chloride in 2 propanol unit pH 2. The resulting dicyclohexylamine hydrochloride was filtered and washed twice with 2-propanol. The combined filtrate and washings were concentrated under reduced pressure. The residue was dissolved in ether (30 ml) and filtered and evaporated. This residue in 2-propanol (25 ml) was cooled to 5° and the pH adjusted to 6-7 with 2% sodium hydroxide in ethanol. The product was collected by filtration, washed with 2-propanol, and then ether. The yield of (R)(+)-1-(3-benzoylthio-1-oxopropyl)-1,2,3,4-tetrahydro-2-quinolinecarboxylic acid sodium salt was 2.0 g, m.p. 140°-144°, [α]D20 +221.3° (c 1, methanol).

Provenance & Evidence