反应详情

1.4 g of 1-ethoxycarbonylimidazole, 2.5 g of ethyl 4-chloromethylphenoxyacetate and 1.7 g of sodium iodide were added to 5 ml of dry acetonitrile, and the mixture was stirred at room temperature for 6 hours. After completion of the reaction, the insoluble materials were filtered off and the filtrate was concentrated under reduced pressure. The residue was triturated with an adequate amount of dry diethyl ether, the resulting powder was collected by filtration and dried to obtain 4.6 g of 1-ethoxycarbonyl-3-(4-ethoxycarbonylmethoxybenzyl)imidazolium iodide (quantitative yield). Colorless hygroscopic amorphous.

1. customAfter completion of the reaction
2. filtrationthe insoluble materials were filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was triturated with an adequate amount of dry diethyl ether
5. filtrationthe resulting powder was collected by filtration
6. customdried