Propargyl bromide → HCID 13109066, compound

Participants

Reaction Steps

12.0 g. (2.7 mmol) (±)-5,6,6a,7-Tetrahydro-1-hydroxy-2,9,10-trimethoxy-4H-dibenzo(de,g)quinoline are dissolved in 25 ml. ethanol and mixed with 560 mg. sodium bicarbonate and 0.26 ml. (2.95 mmol) propargyl bromide. The reaction mixture is stirred for 1 hour at ambient temperature and then for 2 hours at 80° C. under reflux. The usual working up and crystallisation from ethanol gives (±)-6-propargyl-5,6,6a,7-tetrahydro-1-hydroxy-2,9,10-trimethoxy-4H-dibenzo(de,g)quinoline;

Provenance & Evidence