Ammonia → HCID 20450711, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.0 g of 2-pentyl-1,3-benzodioxan-6-carboxylic acid (prepared in accordance with Example 12), 60 ml of chloroform and 2.2 ml of triethylamine is cooled to 0° C. 1.5 ml of ethyl chloroformate are added dropwise while stirring. The mixture is stirred at 0° C. for 1 hour and then ammonia gas is conducted in. The mixture is stirred at room temperature for 5 hours and then evaporated. The residue is stirred up with 100 ml of water and the suspension is suction filtered. The material on the suction filter is dried and boiled up with hexane. There is obtained 2-pentyl-1,3-benzodioxan-6-carboxamide as a beige powder; m.p. 162.5°-163° C.

Provenance & Evidence