HCID 131713597, compound → HCID 22827195, compound

Participants

Reaction Steps

A solution of 10 grams of 1-(L-alanyl)-4-(S)-(phenylmethyl)-L-proline, phenylmethyl ester (liberated from its hydrochloride salt) in 150 ml. of absolute alcohol is hydrogenated in the presence of 1.5 grams of 10% palladium on carbon until the uptake of hydrogen ceases. The mixture is filtered to remove the catalyst and the filtrate is concentrated under reduced pressure to yield the desired 1-(L-alanyl)-4-(S)-(phenylmethyl)-L-proline.

Provenance & Evidence