Sulfuric Acid → HCID 11129651, compound

Participants

Reaction Steps

A mixture of benzyloxycarbonyl-L-alanine (160 g., 0.72 mole), anhydrous dichloromethane (270 ml.), condensed isobutylene (700 ml.), and concentrated sulfuric acid (7.5 ml.) is shaken in a Parr apparatus at room temperature for 3 days. The isobutylene is allowed to evaporate at room temperature overnight and the residue is dissolved in 1 1. of ether. The resulting solution is washed with 1N sodium bicarbonate and brine. After drying over anhydrous MgSO4, the solvent is removed at reduced pressure to give 195 g. of benzyloxy-L-alanine, t-butyl ester as a yellow oil which is used without further purification.

Provenance & Evidence