Methanol → HCID 131713599, compound

HRID 1463032Notes

Reaction equation

HRID 1463032 reaction equation
Cl.[C:2]1([CH2:8][S:9][C@@H:10]2[CH2:14][NH:13][C@H:12]([C:15]([OH:17])=[O:16])[CH2:11]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O.[CH3:22]O>>[ClH:20].[C:2]1([CH2:8][S:9][C@@H:10]2[CH2:14][NH:13][C@H:12]([C:15]([O:17][CH3:22])=[O:16])[CH2:11]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 131713600HCID 131713600, compound

Product 1

HCID 131713599HCID 131713599, compound

Procedure

A solution of cis-4-[(phenylmethyl) thio]-L-proline, hydrochloride in methanol is treated with thionyl chloride according to the procedure of Example 95(e) to yield cis-4-[(phenylmethyl) thio]-L-proline, methyl ester, hydrochloride.

Sources & evidence

ORD record
ord-3070f4babe3b4689b5f86119275a7209
Source dataset
uspto-grants-1984_07
Patent number
US04462943

Reaction notes

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