Sodium Iodide → 1-Pivaloyloxyethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Sodium Iodide	HCID 5238	—
Reactant	1-Iodoethyl 2,2-dimethylpropanoate	HCID 13393064	—
Reactant	Sodium 7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate	HCID 131712445	—
Product	1-Pivaloyloxyethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate	HCID 131713609	—

Reaction Steps

In the same manner as Example 1, sodium 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn-isomer) was reacted with 1-iodoethyl pivalate in the presence of sodium iodide to give 1-pivaloyloxyethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn-isomer), mp 110°-115° C. (decompn.).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04463002
Source dataset	uspto-grants-1984_07
ORD ID	ord-9a049e1ad77b4511880f0850f2f2ac16
Source note	uspto-grants-1984_07