HuagongsheHuagongshe Chemistry Print Report · For research reference only
iodoMethyl 2-Methylpropanoate → Isobutyryloxymethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | iodoMethyl 2-Methylpropanoate | HCID 10376456 | — |
| Reactant | 7-[2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid | HCID 131712444 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Isobutyryloxymethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate | HCID 131713610 | — |
Reaction Steps
In the same manner as Example 8, 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid (syn-isomer) was reacted with iodomethyl isobutyrate in the presence of triethylamine to give isobutyryloxymethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn-isomer), mp 95°-100° C. (decompn.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04463002 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-9758349bf9ff46589a889adebff49538 |
| Source note | uspto-grants-1984_07 |