Malononitrile → [3,4'-BIPYRIDINE]-5-CARBONITRILE,6-METHOXY-

Participants

Reaction Steps

Nantka-Namirski et al. [Pol. J. Pharmacol. Pharm. 30, No. 5, pp. 707-712 (1978)] in a paper entitled "Cancerostatics III. Synthesis and Some Chemical Transformations of 3-cyano-5-(pyridyl-4-)pyrid-2-one" show, inter alia, the reaction of 3-dimethylamino-2-(4-pyridinyl)acrolein with malononitrile and sodium methoxide in methanol at room temperature to produce 3-cyano-2-methoxy-5-(4-pyridinyl)pyridine. Also shown in this paper is 2-chloro-3-cyano-5-(4-pyridinyl)pyridine, disclosed in the instant application as an intermediate to prepare 3-cyano-2-methoxy-5-(4-pyridinyl)pyridine.

Provenance & Evidence