HCID 178418361, compound → HCID 178524844, compound

HRID 1463057Notes

Reaction equation

HRID 1463057 reaction equation
[N:1]1[C:13]2[N:4]([C:5](=[O:14])[N:6]=[C:7]3[C:12]=2[CH:11]=[CH:10][CH:9]=[CH:8]3)[NH:3][C:2]=1[C:15]([O:17]CC1C=CC=CC=1)=[O:16].[H][H]>CO.[Pd]>[N:1]1[C:13]2[N:4]([C:5](=[O:14])[N:6]=[C:7]3[C:12]=2[CH:11]=[CH:10][CH:9]=[CH:8]3)[NH:3][C:2]=1[C:15]([OH:17])=[O:16]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178525050HCID 178525050, compound

Product 1

HCID 178524844HCID 178524844, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5 g (15.6 mmoles) of benzyl 1,2,4-triazolo[1,5-c]quinazolin-5-one-2-carboxylate were dissolved in 250 ml of methanol, 1 g of 5% strength Pd/C was added, and the mixture was then stirred under atmospheric pressure in a hydrogenation apparatus until the absorption of hydrogen was complete. The precipitate was filtered off under suction and dissolved in 50 ml of hot dimethylformamide, the solution was filtered and the solvent was distilled off. The residue was digested with methanol and dried.

Workup

  1. filtrationThe precipitate was filtered off under suction
  2. dissolutiondissolved in 50 ml of hot dimethylformamide
  3. filtrationthe solution was filtered
  4. distillationthe solvent was distilled off
  5. customdried

Sources & evidence

ORD record
ord-a840a2630ba04db7a9eb3d47701e85ee
Source dataset
uspto-grants-1984_07
Patent number
US04463007

Reaction notes

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