Sodium borohydride → HCID 178433453, compound

Participants

Reaction Steps

A solution of ethyl (4-hydroxy-2-methylpyrimid-6-yl)acetate (0.38 g.) in isopropanol (10 ml.) was heated under reflux and treated with sodium borohydride (0.2 g.). The mixture was heated under reflux for 4 hours with the addition of two further portions (0.1 g.) of sodium borohydride after 2 and 3 hours. The mixture was evaporated to dryness and the residue was partitioned between water and ether. The aqueous phase was acidifed with HOAc and then extracted with EtOAc in a continuous extractor for 24 hours. The extract was dried and then evaporated to dryness to give 4-hydroxy-6-(2-hydroxyethyl)-2-methylpyrimidine (0.15 g.) which was used without further purification.

Provenance & Evidence