Sodium hydride → HCID 20451301, compound

Participants

Reaction Steps

A mixture of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-(3-hydroxypropoxy)pyrimidine (293 mg.), a 50% w/w dispersion of sodium hydride in oil (72 mg.) and t-butanol (5 ml.) was stirred at 50° for 0.5 hours and then treated with 2,6-dichloropyrazine (165 mg.) and the resulting mixture was stirred at 50° for 18 hours. The mixture was evaporated to dryness and the residue stirred with a mixture of N aqueous hydrochloric acid and ether. The insoluble white solid was collected to give 6-chloro-2-[3-(4-[2-(2,2,2-trifluoroethyl)guanidino]-pyrimid-2-yloxy)propoxy]pyrazine hydrochloride (70 mg.), m.p. 167°-169°.

Provenance & Evidence