Ammonia → 1-(4-Hydroxybutyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole

HRID 1463065Notes

Reaction equation

HRID 1463065 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH:14][CH2:15][C:16]([F:19])([F:18])[F:17])=S)=[N:7]1.[NH3:20]>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH2:20])=[N:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[N:7]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 53745325HCID 53745325, compound

Product 1

HCID 204513041-(4-Hydroxybutyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazoleYield 82%

Procedure

Mercuric oxide (30.1 g.) was added quickly to a stirred solution of 1-(4-hydroxybutyl)-3-(3-[2,2,2-trifluoroethyl]thioureido)pyrazole (10.4 g.) in methanolic ammonia (5N., 340 ml.). After stirring for 3 hours at room temperature, the mixture was filtered through a pad of diatomaceous earth and the filtrate was evaporated in vacuo to give 1-(4-hydroxybutyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole, m.p. 105°-106° (yield 82%).

Workup

  1. filtrationthe mixture was filtered through a pad of diatomaceous earth
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-6136f124e2b44fe9941a5273c1ec71b1
Source dataset
uspto-grants-1984_07
Patent number
US04463005

Reaction notes

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