HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 3-(2-Bromo-3-oxocyclohex-1-enyl)-hexahydro-1-methylazepin-2-one | HCID 13188836 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one | HCID 11746121 | — |
Reaction Steps
A solution of 3-(2-bromo-3-oxocyclohex-1-enyl)-hexahydro-1-methylazepin-2-one (6 g) in chloroform (60 ml) was treated with 48% HBr in acetic acid (1 ml). After 4 hours, NMR indicated completion. Aqueous ammonia was added and the organic solvent removed under reduced pressure to yeild the title compound as a crystalline solid, m.p. 192°-3° (EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04463177 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-79187fe953d7489994ae276f6fccbd01 |
| Source note | uspto-grants-1984_07 |