HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Aminomebendazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | [2-Amino-1-(propane-2-sulfonyl)-1H-benzimidazol-5-yl](phenyl)methanone | HCID 20451964 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Aminomebendazole | HCID 40320 | — |
Reaction Steps
A slurry of 50 g of 2-amino-1-isopropylsulfonyl-5-benzoylbenzimidazole was heated in 300 ml of acetone and 500 ml of water with 350 ml of 1N sodium hydroxide on a steam bath for two hours. The heating was continued to remove the acetone. Afterwards the solution was cooled to room temperature with stirring. When the cleavage was complete, the precipitate title compound was filtered and washed with water. m/e=237, 160, 105, 77.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04463181 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-c76aba0fcb0246edb9664d6e83616ded |
| Source note | uspto-grants-1984_07 |