Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,3-Dichloro-5-(trifluoromethyl)pyridine | HCID 112234 | — |
| Reactant | HCID 67695614 | HCID 67695614 | — |
| Product | HCID 54185182 | HCID 54185182 | — |
Reaction Steps
Two grams of the above described pyrazolopyridine hydrochloride, 5.0 g potassium carbonate and 5.0 g 2,3-dichloro-5-trifluoromethylpyridine in 20 mL dimethyl formamide was heated to 85° C. for 2 hours. The solution was cooled and diethyl ether was added. Then the solution was washed with saturated NaCl, dried, reduced under vacuum, and purified by column chromatography. Yield was 0.6 g of the title compound as a solid (Compound 27).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05300478 |
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| Source dataset | uspto-grants-1994_04 |
|---|
| ORD ID | ord-b78d864aea2f4849a47e665a70bf8963 |
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| Source note | uspto-grants-1994_04 |
|---|
