Hydrochloric Acid → 1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid (2-methoxy-ethyl)-amide

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Reaction Steps

As described in example 1, 92 mg of [6,8-dimethoxy-4-(2-methoxy-ethylcarbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 22 mg (32%) of 1-aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid (2-methoxy-ethyl)-amide. H1-NMR (Free base) (CDCl3): δ, 8.47 (s, 1H), 7.33 (s, 1H), 6.63 (s, 1H), 6.57 (s, 1H), 4.45 (s, 2H), 3.97 (s, 3H), 3.93 (s, 3H), 3.73 (q, J=4.8 Hz, 2H), 3.63 (d, J=5.1 Hz, 2H), 3.61 (s, 3H), 3.40 (s, 3H); MS: APCI (M+H) calc'd for C16H21N3O4+H 320.4; found 320.2.

Provenance & Evidence