Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 22402944 | HCID 22402944 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 22402967 | HCID 22402967 | 98.4% |
Reaction Steps
A mixture of dimethyl 1-benzyl-2-methyl-4,5-benzimidazoledicarboxylate (5.50 g, 16.2 mmol), methanol, 10N sodium hydroxide (13 mL, 130 mmol) and Water is stirred for 4 hours at 70° C., cooled, acidified to pH 4 with hydrochloric acid and filtered to afford the title product as an off-white solid (4.94 g, 98.4%), mp 224°-226° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05300479 |
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| Source dataset | uspto-grants-1994_04 |
|---|
| ORD ID | ord-0ce6704587e54f7382b3374e6c76817c |
|---|
| Source note | uspto-grants-1994_04 |
|---|
