Water → HCID 22402945, compound

HRID 1463212Notes

Reaction equation

HRID 1463212 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([C:15]([O:17]C)=[O:16])[C:9]([C:11]([O:13]C)=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH3:19].[OH-].[K+].O>CO>[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([C:15]([OH:17])=[O:16])[C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH3:19]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 22402931HCID 22402931, compound

Product 1

HCID 22402945HCID 22402945, compoundYield 91.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of dimethyl 1,2-dimethyl-5,6-benzimidazoledicarboxylate (2.80 g, 10.7 mmol), potassium hydroxide (1.49 g, 26.7 mmol), water and methanol is stirred at room temperature for 16 hours and then concentrated in vacuo. The resultant residue is taken up in a minimal amount of water, cooled, acidified to pH 3 with hydrochloric acid and filtered to give the title product as pink crystals (2.28 g, 91.2%), mp 308°-312° C.

Workup

  1. concentrationconcentrated in vacuo
  2. temperaturecooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-f26300def9984474a996b03ae5c64b43
Source dataset
uspto-grants-1994_04
Patent number
US05300479

Reaction notes

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