HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178480626, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 178510692 | HCID 178510692 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178480626 | HCID 178480626 | — |
Reaction Steps
6-Fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile (1.62 g, 10.0 mmole) was dissolved in 20 mL of N-methylpyrrolidone. N-methylpiperazine (3.0 g, 30.0 mmole) was added and the reaction mixture was warmed for 2 hours at 80°. It was poured into H2O and then the product was filtered off and recrystallized from MeOH-H2H2O to give 1.41 g (58%) of analytically pure product, mp 255°(dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05300498 |
| Source dataset | uspto-grants-1994_04 |
| ORD ID | ord-abbf2ad8e5a541459fa50922d100219b |
| Source note | uspto-grants-1994_04 |