Ammonia → HCID 9884818, compound

Participants

Reaction Conditions

Reaction Steps

7-chloro-2-(2-furyl)-5-[2-(4-methoxyphenyl)ethyl]amino-oxazolo[5,4-d]pyrimidine (0.5 g) and ammonium chloride (0.1 g) were added to a saturated solution of ammonia in ethanol (20 ml) and sealed in a Caries tube. The sealed tube was then heated at 100° C. for 18 hours. The cooled reaction mixture was poured into water (200 ml) and the resultant precipitate removed by filtration. The solid was recrystallised from methanol to afford 7-amino-2-(2-furyl)-5-[2-(4-methoxyphenyl)ethyl]amino-oxazolo[5,4-d]pyrimidine (0.23 g, 48.6%), m.p. 194°-196° C.; microanalysis, found: C, 61.5; H, 4.8; N, 19.5%; C18H17N5O3 requires: C, 61.5; H, 4.9; N, 19.9%; NMR (DMSO-d6); 2.76(t,2H ArCH2), 3.44(brq 2H, CH2NH), 3.72(s, 3H, OMe), 6.70(m, 1 H furyl-H), 6.28(brs, 1H NH), 6.84(d, 2H, ArH), 7.13(complex, 5H ArH, NH2 furyl-H), 7.89(m, 1H, furyl-H); m/e [M+H]+ 352.

Provenance & Evidence