4,6-Diamino-1,2-dihydro-1-hydroxy-2,2-dimethyl-1,3,5-triazine hydrochloride → 4,6-Diamino-1,2-dihydro-1-hydroxy-2,2-dimethyl-1,3,5-triazine

HRID 1463284Notes

Reaction equation

HRID 1463284 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[N:6]([OH:10])[C:5]([CH3:12])([CH3:11])[N:4]=1>O>[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[N:6]([OH:10])[C:5]([CH3:12])([CH3:11])[N:4]=1

Participants

3

Reactant 1

HCID 190899214,6-Diamino-1,2-dihydro-1-hydroxy-2,2-dimethyl-1,3,5-triazine hydrochloride

Product 1

HCID 190899224,6-Diamino-1,2-dihydro-1-hydroxy-2,2-dimethyl-1,3,5-triazineYield 97.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

This compound was prepared in a manner analogous to that of Example 2, using 47.9 grams (0.247 mole) of 4,6-diamino-1,2-dihydro-1-hydroxy-2,2-dimethyl-1,3,5-triazine hydrochloride in 100 ml of water and a 3.5 cm - diameter column containing 350 ml of a strongly basic gel-type ion-exchange resin. An additional 500 ml of water was passed through the column to remove the maximum amount of product. The combined eluants were concentrated under reduced pressure, yielding 37.9 grams of 4,6-diamino-1,2-dihydro-1-hydroxy-2,2-dimethyl-1,3,5-triazine; m.p. 211°-212° C. (dec). The NMR spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in a manner analogous to that of Example 2
  2. additiona 3.5 cm - diameter column containing 350 ml of a strongly basic gel-type ion-exchange resin
  3. customto remove the maximum amount of product
  4. concentrationThe combined eluants were concentrated under reduced pressure

Sources & evidence

ORD record
ord-552772ee017740c883dbb7fd46c33aa7
Source dataset
uspto-grants-1994_04
Patent number
US05300503

Reaction notes

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