HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)benzoyl chloride → HCID 15220955, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)benzoyl chloride | HCID 75257 | — |
| Reactant | 4,5-diphenyltetrahydro-3h-pyrazol-3-one | HCID 270492 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15220955 | HCID 15220955 | 24.4% |
Reaction Steps
A solution of 4,5-diphenyl-3-pyrazolidinone (2.0 g, 8.4 mmol) in 50 mL CH2Cl2 and 5 mL pyridine was treated dropwise with a solution of 3-trifluoromethylbenzoylchloride (1.4 g, 8.4 mmol) in 25 mL CH2Cl2 and stirred overnight. The mixture was washed with 1N HCl, dried over Na2SO4, evaporated, and the product isolated by chromatography (preparative HPLC) as 840 mg (24%) purple foam:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05300514 |
| Source dataset | uspto-grants-1994_04 |
| ORD ID | ord-15f71a2ed19d4274b0c08619fb09856b |
| Source note | uspto-grants-1994_04 |