Benzenemethanamine, 3,4-dichloro- → HCID 15220957, compound

Participants

Reaction Steps

A solution of 1-[(4-nitrophenyl)oxycarbonyl]-4,5-diphenyl-3-pyrazolidinone (1.00 g, 2.48 mmol) and 3,4-dichlorobenzylamine (5 mL) in 50 mL abs. EtOH was heated to reflux for 8 hours. Solvent was removed in vacuo, the residue taken up in CH2Cl2, washed twice with 1N HCl and once with pH 7 buffer, and dried over Na2SO4. After removal of solvent in vacuo, the product was purified by chromatography (0-35% EtOAc:hexane gradient) to give 250 mg (23%) solid:

Provenance & Evidence