Methanol → 3-PYRIDINEPENTANOL

Participants

Reaction Steps

5-(3-Pyridyl)-1-pentyn-4-ol (0.776 g, 4.82 mmol) was added to a stirred suspension of 10% palladium on charcoal (0.2 g) in methanol (30 ml). The reaction was stirred at room temperature under a hydrogen atmosphere for 48 h, by which time hydrogen uptake had ceased. The mixture was filtered through celite and evaporated to provide a yellow oil. Column chromatography (flash silica gel, 5% methanol in ethyl acetate) gave 5-(3-pyridyl)-1-pentanol (0.769 g, 97%) as a colourless oil.

Provenance & Evidence