Hydrochloric Acid → 1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid 4-methoxy-benzylamide hydrochloride

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Reaction Steps

As described in example 1, 46 mg of [6,8-dimethoxy-4-(4-methoxy-benzylcarbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 20 mg (54%) of 1-aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid 4-methoxy-benzylamide hydrochloride. H1-NMR (DMSO): δ 9.26 (br s, 3H), 8.41 (s, 1H), 8.38 (br s, 1H), 7.31 (d, J=8.2 Hz, 2H), 7.09 (s, 1H), 6.90 (d, J=8.2 Hz, 2H), 6.81 (s, 1H), 4.67 (d, J=5.1 Hz, 2H), 4.44 (d, J=5.5 Hz, 2H), 3.96 (s, 3H), 3.76 (s, 3H), 3.71 (s, 3H); MS: APCI (M+H) calc'd for C21H23N3O4+H 382.4; found 382.2.

Provenance & Evidence