Acetic Anhydride → HCID 11723217, compound

HRID 1463427Notes

Reaction equation

HRID 1463427 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([OH:20])[C:8]2[C:13]([CH3:14])=[C:12]([O:15][CH3:16])[C:11]([CH3:17])=[CH:10][C:9]=2[O:18][CH3:19])[CH:2]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>N1C=CC=CC=1>[C:21]([O:20][CH:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:8]1[C:13]([CH3:14])=[C:12]([O:15][CH3:16])[C:11]([CH3:17])=[CH:10][C:9]=1[O:18][CH3:19])(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 10445976HCID 10445976, compound

Product 1

HCID 11723217HCID 11723217, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
80 °C

Procedure

A mixture comprising 3.2 g of α-(3-pyridyl)-2,5-dimethoxy-4,6-dimethylbenzyl alcohol obtained by the method described in any of the Production Examples 1, 2 and 3, 5 ml of pyridine and 5 ml of acetic anhydride was heated and stirred at 80° C. for 1 hour. Then the pyridine and acetic anhydride were distilled off and the residue was purified by silica gel column chromatography. Thus 2.9 g of the title compound was obtained.

Workup

  1. customobtained by the method
  2. temperaturewas heated
  3. distillationThen the pyridine and acetic anhydride were distilled off
  4. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-c71d3612df3b459ea2021189b40b9165
Source dataset
uspto-grants-1994_04
Patent number
US05300518

Reaction notes

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