HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 114812-34-9
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | methyl (S)-1-ethyl-2-pyrrolidinecarboxylate hydrochloride | HCID 86747729 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 114812-34-9 | HCID 10866443 | 632.9% |
Reaction Steps
Crude methyl (S)-1-ethyl-2-pyrrolidinecarboxylate hydrochloride (2.1 g, 0.01 mol; Example 6A) and NaCN (50 mg, 0.001 mol) in 30 ml 9M NH3 in MeOH was heated to 45° C. in a sealed glass flask for 2 days. GLC showed a conversion of 95% and usual work-up afforded 0.9 g (63%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05300660 |
| Source dataset | uspto-grants-1994_04 |
| ORD ID | ord-4b36c8c9c2f3439797ae430952b93e34 |
| Source note | uspto-grants-1994_04 |