Hydrochloric Acid → Methyl 1-(4'-hydroxymethylphenyl)cyclopent-3-ene-1-carboxylate

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Reaction Steps

To a solution of the title compound of Step 2, above, (1.8 g, 5.23 mmol) in 25 ml THF was added n-Bu4NF (1.5 g, 5.75 mmol), and the resulting solution was stirred at ambient temperature for 3 hours. The mixture was poured into 50 ml 1N HCl and extracted (EtOAc, 4×30 ml). The combined extracts were dried over MgSO4, filtered and concentrated to yield 1.51 g of the title compound as an oil which was used crude in the next step.

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